Long Noncoding RNAs and Repetitive Elements: Junk or Intimate Evolutionary Partners?
Trends Genet
; 35(12): 892-902, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31662190
ABSTRACT
Our recent ability to sequence entire genomes, along with all of their transcribed RNAs, has led to the surprising finding that only â¼1% of the human genome is used to encode proteins. This finding has led to vigorous debate over the functional importance of the transcribed but untranslated portions of the genome. Currently, scientists tend to assume coding genes are functional until proven not to be, while the opposite is true for noncoding genes. This review takes a new look at the evidence for and against widespread noncoding gene functionality. We focus in particular on long noncoding RNA (noncoding RNAs longer than 200 nucleotides) genes and their 'junk' associates, transposable elements, and satellite repeats. Taken together, the suggestion put forward is that more of this junk DNA may be functional than nonfunctional and that noncoding RNAs and transposable elements act symbiotically to drive evolution.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Evolução Molecular
/
Sequências Repetitivas Dispersas
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RNA Longo não Codificante
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Genet
Assunto da revista:
GENETICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá