Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Trends Cell Biol
; 29(12): 929-939, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31662235
ABSTRACT
MHC class I presentation of short peptides enables CD8+ T cell (TCD8+) immunosurveillance of tumors and intracellular pathogens. A key feature of the class I pathway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high selectivity of the access of protease-generated peptides to class I molecules. Similarly, in professional antigen-presenting cells, peptides from minute amounts of proteins introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides. Here, we propose that antigen processing is based on substrate channeling and review recent studies from the antigen processing and cell biology fields that provide a starting point for testing this hypothesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
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Apresentação de Antígeno
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Linfócitos T CD8-Positivos
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Vigilância Imunológica
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Células Apresentadoras de Antígenos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2019
Tipo de documento:
Article