Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study.
J Nutr
; 150(5): 1214-1222, 2020 05 01.
Article
em En
| MEDLINE
| ID: mdl-31665380
ABSTRACT
BACKGROUND:
Few studies have assessed the associations of ceramides and sphingomyelins (SMs) with diabetes in humans.OBJECTIVE:
We assessed associations of 15 circulating ceramides and SM species with incident diabetes in 2 studies.METHODS:
The analysis included 435 American-Indian participants from the Strong Heart Study (nested case-control design for analyses; mean age 57 y; 34% male; median time until diabetes 4.3 y for cases) and 1902 participants from the Strong Heart Family Study (prospective design for analyses; mean age 37 y; 39% male; median 12.5 y of follow-up). Sphingolipid species were measured using stored plasma samples by sequential LC and MS. Using logistic regression and parametric survival models within studies, and an inverse-variance-weighted meta-analysis across studies, we examined associations of 15 ceramides and SM species with incident diabetes.RESULTS:
There were 446 cases of incident diabetes across the studies. Higher circulating concentrations of ceramides containing stearic acid (Cer-18), arachidic acid (Cer-20), and behenic acid (Cer-22) were each associated with a higher risk of diabetes. The RRs for incident diabetes per 1 SD of each log ceramide species (µM) were 1.22 (95% CI 1.09, 1.37) for Cer-18, 1.18 (95% CI 1.06, 1.31) for Cer-20, and 1.20 (95% CI 1.08, 1.32) for Cer-22. Although the magnitude of the risk estimates for the association of ceramides containing lignoceric acid (Cer-24) with diabetes was similar to those for Cer-18, Cer-20, and Cer-22 (RR = 1.13; 95% CI 1.01, 1.26), the association was not statistically significant after correction for multiple testing (P = 0.007). Ceramides carrying palmitic acid (Cer-16), SMs, glucosyl-ceramides, or a lactosyl-ceramide were not associated with diabetes risk.CONCLUSIONS:
Higher concentrations of circulating Cer-18, Cer-20, and Cer-22 were associated with a higher risk of developing diabetes in 2 studies of American-Indian adults. This trial was registered at clinicaltrials.gov as NCT00005134.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Indígenas Norte-Americanos
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Ceramidas
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Diabetes Mellitus Tipo 2
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos