[Bilateral adrenal hemorrhage under apixaban in primary antiphospholipid syndrome]. / Nécrose hémorragique bilatérale des surrénales sous apixaban : penser au syndrome des antiphospholipides ?
Rev Med Interne
; 41(7): 489-492, 2020 Jul.
Article
em Fr
| MEDLINE
| ID: mdl-31672255
ABSTRACT
INTRODUCTION:
Adrenal hemorrhage is a classical but rare complication of antiphospholipid syndrome, revealing diagnosis in one third of the cases. Anti-vitamin K therapy is the standard treatment but direct oral anticoagulants are discussed as an alternative. In the latest recommendations, it is advised not to use direct oral anticoagulants in the setting of antiphospholipid syndrome. CASE REPORT We present a case of bilateral adrenal hemorrhage revealing primary antiphospholipid syndrome with triple positive antibody profile, in a 47-year-old man treated by apixaban for previous venous thromboembolism.CONCLUSION:
To our knowledge, it is the first case of adrenal hemorrhage occurring during apixaban treatment in a patient with antiphospholipid syndrome. This case illustrates the inefficacy of direct oral anticoagulants to prevent thrombotic events in antiphospholipid syndrome, in accordance with the latest recommendations.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Piridonas
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Síndrome Antifosfolipídica
/
Doenças das Glândulas Suprarrenais
/
Hemorragia
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Humans
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Male
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Middle aged
Idioma:
Fr
Revista:
Rev Med Interne
Ano de publicação:
2020
Tipo de documento:
Article