A MYC-GCN2-eIF2&#945; negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.

Schmidt, Stefanie; Gay, David; Uthe, Friedrich Wilhelm; Denk, Sarah; Paauwe, Madelon; Matthes, Niels; Diefenbacher, Markus Elmar; Bryson, Sheila; Warrander, Fiona Clare; Erhard, Florian; Ade, Carsten Patrick; Baluapuri, Apoorva; Walz, Susanne; Jackstadt, Rene; Ford, Catriona; Vlachogiannis, Georgios; Valeri, Nicola; Otto, Christoph; Schülein-Völk, Christina; Maurus, Katja; Schmitz, Werner; Knight, John Raymond Philip; Wolf, Elmar; Strathdee, Douglas; Schulze, Almut; Germer, Christoph-Thomas; Rosenwald, Andreas; Sansom, Owen James; Eilers, Martin; Wiegering, Armin

A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.

Schmidt, Stefanie; Gay, David; Uthe, Friedrich Wilhelm; Denk, Sarah; Paauwe, Madelon; Matthes, Niels; Diefenbacher, Markus Elmar; Bryson, Sheila; Warrander, Fiona Clare; Erhard, Florian; Ade, Carsten Patrick; Baluapuri, Apoorva; Walz, Susanne; Jackstadt, Rene; Ford, Catriona; Vlachogiannis, Georgios; Valeri, Nicola; Otto, Christoph; Schülein-Völk, Christina; Maurus, Katja; Schmitz, Werner; Knight, John Raymond Philip; Wolf, Elmar; Strathdee, Douglas; Schulze, Almut; Germer, Christoph-Thomas; Rosenwald, Andreas; Sansom, Owen James; Eilers, Martin; Wiegering, Armin.

Afiliação

Schmidt S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Gay D; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
Uthe FW; CRUK Beatson Institute, Glasgow, UK.
Denk S; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Paauwe M; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
Matthes N; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Diefenbacher ME; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
Bryson S; CRUK Beatson Institute, Glasgow, UK.
Warrander FC; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Erhard F; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
Ade CP; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Baluapuri A; CRUK Beatson Institute, Glasgow, UK.
Walz S; CRUK Beatson Institute, Glasgow, UK.
Jackstadt R; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Ford C; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Vlachogiannis G; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Valeri N; Comprehensive Cancer Center Mainfranken, Core Unit Bioinformatics, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Otto C; CRUK Beatson Institute, Glasgow, UK.
Schülein-Völk C; CRUK Beatson Institute, Glasgow, UK.
Maurus K; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Schmitz W; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Knight JRP; Department of Medicine, The Royal Marsden NHS Trust, London, UK.
Wolf E; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
Strathdee D; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Schulze A; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
Germer CT; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Rosenwald A; CRUK Beatson Institute, Glasgow, UK.
Sansom OJ; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.
Eilers M; CRUK Beatson Institute, Glasgow, UK.
Wiegering A; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany.

Nat Cell Biol ; 21(11): 1413-1424, 2019 11.

Article em En | MEDLINE | ID: mdl-31685988

Assuntos

Neoplasias Colorretais/genética; Fator de Iniciação 2 em Eucariotos/genética; Regulação Neoplásica da Expressão Gênica; Proteínas Serina-Treonina Quinases/genética; Proteínas Proto-Oncogênicas c-myc/genética; Proteína da Polipose Adenomatosa do Colo/genética; Proteína da Polipose Adenomatosa do Colo/metabolismo; Animais; Apoptose/genética; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Colo/metabolismo; Colo/patologia; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/mortalidade; Neoplasias Colorretais/patologia; Fator de Iniciação 2 em Eucariotos/metabolismo; Fator de Iniciação 2B em Eucariotos/antagonistas & inibidores; Fator de Iniciação 2B em Eucariotos/genética; Fator de Iniciação 2B em Eucariotos/metabolismo; Retroalimentação Fisiológica; Feminino; Células HCT116; Células HEK293; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Biossíntese de Proteínas; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Proto-Oncogênicas c-myc/metabolismo; Transdução de Sinais; Análise de Sobrevida; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Fator de Iniciação 2 em Eucariotos / Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas c-myc / Proteínas Serina-Treonina Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Cell Biol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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