Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

Morris, Daniel L; Kastner, David W; Johnson, Sabrina; Strub, Marie-Paule; He, Yi; Bleck, Christopher K E; Lee, Duck-Yeon; Tjandra, Nico

Morris, Daniel L; Kastner, David W; Johnson, Sabrina; Strub, Marie-Paule; He, Yi; Bleck, Christopher K E; Lee, Duck-Yeon; Tjandra, Nico.

Afiliação

Morris DL; Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Kastner DW; Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Johnson S; Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Strub MP; Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
He Y; Protein Expression Facility, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Bleck CKE; Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Lee DY; Protein Expression Facility, Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20814.
Tjandra N; Electron Microscopy Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892.

J Biol Chem ; 294(50): 19055-19065, 2019 12 13.

Article em En | MEDLINE | ID: mdl-31690630

Assuntos

Apoptose; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Membranas Mitocondriais/metabolismo; Peptídeos/metabolismo; Proteína X Associada a bcl-2/metabolismo; Permeabilidade da Membrana Celular; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/química; Mutação; Peptídeos/química; Conformação Proteica; Proteína X Associada a bcl-2/química; Proteína X Associada a bcl-2/genética

Palavras-chave

B-cell lymphoma 2 (Bcl-2) family; BCL-2-associated X apoptosis regulator (BAX); Bax; apoptosis; conformational change; electron microscopy; fibers; fibril; fibrillation; humanin; mitochondrial apoptosis; protein aggregation; ß-sheet

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Apoptose / Peptídeos e Proteínas de Sinalização Intracelular / Membranas Mitocondriais / Proteína X Associada a bcl-2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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