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Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
Gómez-Banoy, Nicolás; Guseh, J Sawalla; Li, Ge; Rubio-Navarro, Alfonso; Chen, Tong; Poirier, BreAnne; Putzel, Gregory; Rosselot, Carolina; Pabón, Maria A; Camporez, João Paulo; Bhambhani, Vijeta; Hwang, Shih-Jen; Yao, Chen; Perry, Rachel J; Mukherjee, Sushmita; Larson, Martin G; Levy, Daniel; Dow, Lukas E; Shulman, Gerald I; Dephoure, Noah; Garcia-Ocana, Adolfo; Hao, Mingming; Spiegelman, Bruce M; Ho, Jennifer E; Lo, James C.
Afiliação
  • Gómez-Banoy N; Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Guseh JS; Corrigan Minehan Heart Center, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Li G; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
  • Rubio-Navarro A; Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Chen T; Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Poirier B; Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Putzel G; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Rosselot C; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pabón MA; Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Camporez JP; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
  • Bhambhani V; Corrigan Minehan Heart Center, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Hwang SJ; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Yao C; Framingham Heart Study, Framingham, MA, USA.
  • Perry RJ; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Mukherjee S; Framingham Heart Study, Framingham, MA, USA.
  • Larson MG; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
  • Levy D; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
  • Dow LE; Framingham Heart Study, Framingham, MA, USA.
  • Shulman GI; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Dephoure N; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Garcia-Ocana A; Framingham Heart Study, Framingham, MA, USA.
  • Hao M; Sandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Spiegelman BM; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
  • Ho JE; Sandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Lo JC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Med ; 25(11): 1739-1747, 2019 11.
Article em En | MEDLINE | ID: mdl-31700183
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator D do Complemento / Complemento C3a / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Fosfatases da Proteína Quinase Ativada por Mitógeno / Fosfatases de Especificidade Dupla Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator D do Complemento / Complemento C3a / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Fosfatases da Proteína Quinase Ativada por Mitógeno / Fosfatases de Especificidade Dupla Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos