PTEN Nuclear Functions.
Cold Spring Harb Perspect Med
; 10(5)2020 05 01.
Article
em En
| MEDLINE
| ID: mdl-31712221
ABSTRACT
For years, clinical and basic researchers have been aware of the presence of PTEN in the nucleus in cell culture, animal models, and both healthy and diseased human tissues. Despite the early recognition of nuclear PTEN, the understanding of the mechanisms of its nuclear localization, function in the nucleus, and importance in biology and human disease has been lacking. Over the last decade, emerging concepts for the complex involvement of nuclear PTEN in a variety of processes, including genome maintenance and DNA repair, cell-cycle control, gene expression, and DNA replication, are illuminating what could prove to be the key path toward a full understanding of PTEN function in health and disease. Dysregulation of nuclear PTEN is now considered an important aspect of the etiology of many pathologic conditions, prompting reconsideration of the therapeutic approaches aimed at countering the consequences of PTEN deficiency. This new knowledge is fueling the development of innovative therapeutic modalities for a broad spectrum of human conditions, from cancer and metabolic diseases, to neurological disorders and autism.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Reparo do DNA
/
PTEN Fosfo-Hidrolase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá