Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(III) Complexes Based on the Androst-16-en-3-ol Framework.
Inorg Chem
; 58(23): 15917-15926, 2019 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-31714764
ABSTRACT
A range of novel cyclometalated ruthenium(II) and iridium(III) complexes with a steroidal backbone based on androsterone were synthesized and characterized by NMR spectroscopy and X-ray crystallography. Their cytotoxic properties in RT112 and RT112 cP (cisplatin-resistant) cell lines as well as in MCF7 and somatic fibroblasts were compared with those of the corresponding nonsteroidal complexes and the noncyclometalated pyridyl complexes as well as with cisplatin as reference. All steroidal complexes were more active in RT112 cP cells than cisplatin, whereby the cyclometalated pyridinylphenyl complexes based on 5c showed high cytotoxicity while maintaining low resistant factors of 0.33 and 0.50.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rutênio
/
Complexos de Coordenação
/
Androstenóis
/
Irídio
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Inorg Chem
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha