Experiment, theory, and the keratocyte: An ode to a simple model for cell motility.
Semin Cell Dev Biol
; 100: 143-151, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31718950
ABSTRACT
Lamellipodial locomotion of fish keratocytes is one of the simplest examples of actin-based motility. In the last four decades, fruitful collaborations between experimentalists and theorists have resulted in a detailed mechanistic understanding of the self-organized lamellipodial engine powering keratocyte motility. Here we review the mechanical mechanisms underlying keratocyte migration, highlighting the interplay between modeling and experiments that led to insights regarding the dynamics of actin network organization, cell shape, and self-polarization. We discuss how to apply lessons learnt from keratocytes to understand cell migration in more complex, physiological contexts.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Células Epidérmicas
/
Modelos Biológicos
Limite:
Animals
Idioma:
En
Revista:
Semin Cell Dev Biol
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos