The role of interleukin-17 in tumor development and progression.
J Exp Med
; 217(1)2020 01 06.
Article
em En
| MEDLINE
| ID: mdl-31727782
ABSTRACT
IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate IL-17 as a link among inflammation, wound healing, and cancer. While IL-17-mediated production of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigenesis. Here, we review the pleotropic impacts of IL-17 on cancer biology, focusing how IL-17-mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-promoting function and discussing the implications in therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-17
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Carcinogênese
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2020
Tipo de documento:
Article