Your browser doesn't support javascript.
loading
Seroprevalence of anti-tetanus antibodies in mothers and cord blood and associated factors in health-care settings in Lao People's Democratic Republic.
Ounnavong, Phoumsavath; Chanthavilay, Phetsavanh; Khampanisong, Phonepaseuth; Reinharz, Daniel; Muller, Claude P; Black, Antony P.
Afiliação
  • Ounnavong P; Institut de la Francophonie pour la Medecine Tropicale, Lao Democratic People's Republic.
  • Chanthavilay P; Institut de la Francophonie pour la Medecine Tropicale, Lao Democratic People's Republic.
  • Khampanisong P; Lao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, Lao Democratic People's Republic.
  • Reinharz D; Institut de la Francophonie pour la Medecine Tropicale, Lao Democratic People's Republic; Department of Social and Preventive Medicine, Laval University, Canada(2).
  • Muller CP; Lao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, Lao Democratic People's Republic; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Laboratoire Nationale de Santé, Dudelange, Luxembourg.
  • Black AP; Lao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, Lao Democratic People's Republic. Electronic address: a.black@pasteur.la.
Vaccine ; 38(5): 1234-1240, 2020 01 29.
Article em En | MEDLINE | ID: mdl-31735506
BACKGROUND: Maternal neonatal tetanus (MNT) was eliminated from Lao People's Democratic Republic (PDR) in 2014. WHO recommends 80% coverage of 2 or more tetanus vaccinations (TT2+) in pregnancy to maintain MNT control. Vaccination coverage in Lao PDR varies among regions although the reasons are not clear. METHODS: 185 pregnant women giving birth in three district hospitals in Savannakhet province, Lao PDR were recruited. A questionnaire was administered to determine factors associated with seroprotection and blood was taken from mother and cord blood to be tested for anti-tetanus antibodies by ELISA. RESULTS: 77% of mothers and 79% of newborns had sufficiently protective antibody titres (>0.5 IU/ml) against tetanus. Only 70% of the mothers received one dose of TT vaccination during antenatal care (ANC) consultation and 45% received the recommended two injections. Although most of the vaccination took place during ANC 1 and 2, many were missed at these time-points. Anti-tetanus seroprotection in the mothers was associated with maternal age, number of ANC visits, number of TT vaccinations during and before pregnancy and gestational age. CONCLUSION: Seroprevalence of anti-tetanus antibodies in mothers and newborns was intermediate but TT2+ coverage was low in healthcare settings in Lao PDR. TT2+ coverage during ANC is likely to be significantly lower in settings with less robust ANC practices. Missed opportunities to vaccinate in ANC 1 and 2 suggest a need to promote vaccine awareness and vaccination at first ANC visit. A booster dose of TT containing vaccine should be considered for children aged between 4 and 7 years old.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tétano / Estudos Soroepidemiológicos / Sangue Fetal / Anticorpos Antibacterianos / Mães Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: Asia Idioma: En Revista: Vaccine Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tétano / Estudos Soroepidemiológicos / Sangue Fetal / Anticorpos Antibacterianos / Mães Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: Asia Idioma: En Revista: Vaccine Ano de publicação: 2020 Tipo de documento: Article