Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia.
Cutan Ocul Toxicol
; 39(1): 43-53, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31741401
ABSTRACT
Purpose:
Androgenic alopecia (AGA) is a condition of progressive hair loss and involves follicular miniaturization triggered mainly due to varying levels of androgen besides environmental and genetic factors, which may also play some role. Minoxidil (MXD) has been considered as most effective therapeutic moiety to treat this disorder. Another drug Tretinoin (TRET) is known for its comedolytic activity and is reported to enhance percutaneous absorption of MXD. Presently both these drugs are being utilized for treatment of androgenic alopecia (AGA) in solution form which poses several problems in terms of poor solubility of drug, frequency of application and side effects.Materials andmethods:
Current work investigates liposomal hydrogel system for simultaneous delivery of MXD and TRET to overcome the limitations of existing formulation. Successful development of liposomes was commenced by thin film hydration method and various parameters affecting desired characteristics like size, morphology, entrapment efficiency; stability and ex vivo permeation were optimized. The formulated liposomes were further characterized for various physicochemical properties and evaluated for in vivo irritancy study in animals.Results anddiscussion:
Results suggested prepared liposomes to be stable, homogenous and capable to hold both the drugs within. Association with hydrogel enhanced the permeation of MXD through skin ex vivo but TRET retained on the skin. Liposome loaded hydrogel was found to be non-irritant to skin.Conclusion:
Overall developed system showed potential for effective and simultaneous delivery of both the drugs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Hidrogéis
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Lipossomos
/
Minoxidil
Limite:
Animals
Idioma:
En
Revista:
Cutan Ocul Toxicol
Assunto da revista:
DERMATOLOGIA
/
OFTALMOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia