Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.

Zhang, Jiaming; Hou, Deyin; Annis, James; Sargolzaeiaval, Forough; Appelbaum, Julia; Takahashi, Eishi; Martin, George M; Herr, Alan; Oshima, Junko

Zhang, Jiaming; Hou, Deyin; Annis, James; Sargolzaeiaval, Forough; Appelbaum, Julia; Takahashi, Eishi; Martin, George M; Herr, Alan; Oshima, Junko.

Afiliação

Zhang J; Department of Pathology, University of Washington, Seattle, Washington.
Hou D; Department of Pathology, University of Washington, Seattle, Washington.
Annis J; Quellos High-Throughput Screening Core, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, Washington.
Sargolzaeiaval F; Department of Pathology, University of Washington, Seattle, Washington.
Appelbaum J; Department of Pathology, University of Washington, Seattle, Washington.
Takahashi E; Department of Dermatology, National Hospital Organization Tochigi Medical Center, Tochigi, Japan.
Martin GM; Department of Pathology, University of Washington, Seattle, Washington.
Herr A; Department of Pathology, University of Washington, Seattle, Washington.
Oshima J; Department of Pathology, University of Washington, Seattle, Washington.

DNA Cell Biol ; 39(1): 50-56, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31750734

Assuntos

DNA Polimerase III/genética; Desoxirribonucleotídeos/metabolismo; Fibroblastos/metabolismo; Mutação; Sequência de Bases; Sítios de Ligação/genética; Linhagem Celular; DNA Polimerase III/antagonistas & inibidores; DNA Polimerase III/metabolismo; Surdez/genética; Surdez/metabolismo; Exonucleases/genética; Exonucleases/metabolismo; Fibroblastos/citologia; Fibroblastos/efeitos dos fármacos; Humanos; Hidroxiureia/farmacologia; Lipodistrofia/genética; Lipodistrofia/metabolismo; Lipodistrofia/patologia; Interferência de RNA; Proteína 1 com Domínio SAM e Domínio HD/genética; Proteína 1 com Domínio SAM e Domínio HD/metabolismo; Síndrome

Palavras-chave

fibroblasts; human; mutation; polymerase delta; siRNA screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desoxirribonucleotídeos / DNA Polimerase III / Fibroblastos / Mutação Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: DNA Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article

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