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In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages.
Duschmalé, Jörg; Hansen, Henrik Frydenlund; Duschmalé, Martina; Koller, Erich; Albaek, Nanna; Møller, Marianne Ravn; Jensen, Klaus; Koch, Troels; Wengel, Jesper; Bleicher, Konrad.
Afiliação
  • Duschmalé J; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Hansen HF; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Femtidsvej 3, DK-2970 Hørsholm, Denmark.
  • Duschmalé M; Pharmaceutical Sciences, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Koller E; Pharmaceutical Sciences, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Albaek N; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Femtidsvej 3, DK-2970 Hørsholm, Denmark.
  • Møller MR; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Femtidsvej 3, DK-2970 Hørsholm, Denmark.
  • Jensen K; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Femtidsvej 3, DK-2970 Hørsholm, Denmark.
  • Koch T; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Femtidsvej 3, DK-2970 Hørsholm, Denmark.
  • Wengel J; Biomolecular Nanoscale Engineering Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, DK-5230 Odense M, Denmark.
  • Bleicher K; RNA Therapeutics, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
Nucleic Acids Res ; 48(1): 63-74, 2020 01 10.
Article em En | MEDLINE | ID: mdl-31754711
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Fosfatos / Apolipoproteína B-100 / Oligonucleotídeos Fosforotioatos / RNA Longo não Codificante Limite: Animals / Female / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Fosfatos / Apolipoproteína B-100 / Oligonucleotídeos Fosforotioatos / RNA Longo não Codificante Limite: Animals / Female / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça