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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Wang, Sijie; Denton, Kyle E; Hobbs, Kathryn F; Weaver, Tyler; McFarlane, James M B; Connelly, Katelyn E; Gignac, Michael C; Milosevich, Natalia; Hof, Fraser; Paci, Irina; Musselman, Catherine A; Dykhuizen, Emily C; Krusemark, Casey J.
Afiliação
  • Wang S; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University and Purdue University Center for Cancer Research , 575 Stadium Mall Drive , West Lafayette , Indiana 47906 , United States.
  • Denton KE; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University and Purdue University Center for Cancer Research , 575 Stadium Mall Drive , West Lafayette , Indiana 47906 , United States.
  • Hobbs KF; Department of Biochemistry, Carver College of Medicine , University of Iowa , 51 Newton Road , Iowa City , Iowa 52242 , United States.
  • Weaver T; Department of Biochemistry, Carver College of Medicine , University of Iowa , 51 Newton Road , Iowa City , Iowa 52242 , United States.
  • McFarlane JMB; Department of Chemistry , University of Victoria , Victoria V8W 3V6 , Canada.
  • Connelly KE; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University and Purdue University Center for Cancer Research , 575 Stadium Mall Drive , West Lafayette , Indiana 47906 , United States.
  • Gignac MC; Department of Chemistry , University of Victoria , Victoria V8W 3V6 , Canada.
  • Milosevich N; Department of Chemistry , University of Victoria , Victoria V8W 3V6 , Canada.
  • Hof F; Department of Chemistry , University of Victoria , Victoria V8W 3V6 , Canada.
  • Paci I; Department of Chemistry , University of Victoria , Victoria V8W 3V6 , Canada.
  • Musselman CA; Department of Biochemistry, Carver College of Medicine , University of Iowa , 51 Newton Road , Iowa City , Iowa 52242 , United States.
  • Dykhuizen EC; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University and Purdue University Center for Cancer Research , 575 Stadium Mall Drive , West Lafayette , Indiana 47906 , United States.
  • Krusemark CJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University and Purdue University Center for Cancer Research , 575 Stadium Mall Drive , West Lafayette , Indiana 47906 , United States.
ACS Chem Biol ; 15(1): 112-131, 2020 01 17.
Article em En | MEDLINE | ID: mdl-31755685
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Biblioteca Gênica / Inibidores Enzimáticos / Complexo Repressor Polycomb 1 / Ligantes / Antineoplásicos Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Biblioteca Gênica / Inibidores Enzimáticos / Complexo Repressor Polycomb 1 / Ligantes / Antineoplásicos Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos