Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity.

Penniman, Christie M; Suarez Beltran, Pablo A; Bhardwaj, Gourav; Junck, Taylor L; Jena, Jayashree; Poro, Kennedy; Hirshman, Michael F; Goodyear, Laurie J; O'Neill, Brian T

Penniman, Christie M; Suarez Beltran, Pablo A; Bhardwaj, Gourav; Junck, Taylor L; Jena, Jayashree; Poro, Kennedy; Hirshman, Michael F; Goodyear, Laurie J; O'Neill, Brian T.

Afiliação

Penniman CM; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Suarez Beltran PA; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Bhardwaj G; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Junck TL; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Jena J; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Poro K; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Hirshman MF; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Goodyear LJ; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
O'Neill BT; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: Brian-Oneill@uiowa.edu.

Mol Metab ; 30: 203-220, 2019 12.

Article em En | MEDLINE | ID: mdl-31767172

Assuntos

Fatores de Transcrição Forkhead/metabolismo; Resistência à Insulina/fisiologia; Obesidade/metabolismo; Animais; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Dieta Hiperlipídica; Metabolismo Energético; Feminino; Proteína Forkhead Box O1/genética; Proteína Forkhead Box O1/metabolismo; Proteína Forkhead Box O3/genética; Proteína Forkhead Box O3/metabolismo; Fatores de Transcrição Forkhead/genética; Teste de Tolerância a Glucose; Insulina/metabolismo; Resistência à Insulina/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Músculo Esquelético/metabolismo; Receptor de Insulina/metabolismo; Caracteres Sexuais; Fatores Sexuais; Transdução de Sinais; Aumento de Peso

Palavras-chave

Diet-induced obesity; FoxO; Gender differences; Glucose uptake; High-fat diet; Insulin resistance; Muscle hypertrophy; Sexual dimorphism

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Fatores de Transcrição Forkhead / Obesidade Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Mol Metab Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google