Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?
Front Pharmacol
; 10: 1256, 2019.
Article
em En
| MEDLINE
| ID: mdl-31780927
ABSTRACT
Platelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited evidence is so far available concerning the effects of antiplatelet agents on the release of platelet-derived extracellular vesicles. In the present narrative review, the mechanisms leading to vesiculation in platelets and the pathophysiological processes implicated will be discussed. This will be followed by a summary of the present evidence concerning the effects of antiplatelet agents under experimental conditions and in clinical settings.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Pharmacol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália