Update on pediatric hyperthyroidism.
Curr Opin Endocrinol Diabetes Obes
; 27(1): 70-76, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31789723
ABSTRACT
PURPOSE OF REVIEW This review is intended to highlight recent studies which provide new data on the epidemiology and management of children with hyperthyroidism, including neonates. RECENT FINDINGS:
A French study demonstrates differences in age-related trends in incidence of hyperthyroidism in males versus females and suggests the overall incidence may be increasing. New studies confirm the effectiveness and safety of long-term medical therapy (up to 10 years), including from the first randomized trial of short-term versus long-term therapy. Radioiodine ablation (RAI) is the main alternative therapy, though surgery may have some advantages if done in a high-volume center; using higher weight-based doses of I-131 (250âµCI/g thyroid tissue) could increase proportion of patients achieving hypothyroidism and decrease repeat ablations. Maternal or neonatal thyroid-stimulating hormone (TSH) receptor antibodies in children of mothers with Graves' disease, and TSH at 3-7 days of age are good predictors of which neonates will have problems.SUMMARY:
More research is needed on the epidemiology of Graves' disease. Long-term medical therapy well past two years should be considered an option in compliant patients to decrease the number who need definitive therapy. For those receiving RAI, a dose of about 250âµCI/g thyroid tissue should result in fewer cases of persistent hyperthyroidism than lower doses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipertireoidismo
Tipo de estudo:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Limite:
Child
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Female
/
Humans
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Male
/
Newborn
Idioma:
En
Revista:
Curr Opin Endocrinol Diabetes Obes
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos