Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors.
Bioorg Chem
; 94: 103455, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31791680
ABSTRACT
Novel ammonium and betaine derivatives of p-tert-butylthiacalix[4]arene in cone and 1,3-alternate conformation were synthesized with high yields for the first time. The obtained compounds form in water spherical nanoparticles. It was shown by molecular docking calculations and in vitro experiments that amino and betaine derivatives can inhibit acetylcholinesterase and butyrylcholinesterase on the level of pyridostigmine while the toxicity of the obtained compounds is much lower than that of pyridostigmine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Acetilcolinesterase
/
Sulfetos
/
Betaína
/
Butirilcolinesterase
/
Inibidores da Colinesterase
/
Aminas
Limite:
Humans
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2020
Tipo de documento:
Article