Covalent Small Molecules as Enabling Platforms for Drug Discovery.
Chembiochem
; 21(8): 1080-1100, 2020 04 17.
Article
em En
| MEDLINE
| ID: mdl-31833626
ABSTRACT
Covalent drugs have experienced significant renewed interest in drug discovery. This resurgence has been accompanied by a better understanding of the reactivity relationships required to engage selective covalent bonds between nucleophilic proteins and electrophilic small molecules. As a result, researchers have come to the realisation that covalent molecules could also represent useful and novel tools aimed at supporting medicinal chemistry programmes. This review surveys the increasing number of drug discovery platforms employing covalent chemistries, and highlights the utility of these techniques for identifying and characterising small molecules and biological targets.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Química Farmacêutica
/
Inibidores Enzimáticos
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Enzimas
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Bibliotecas de Moléculas Pequenas
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Descoberta de Drogas
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Terapia de Alvo Molecular
Limite:
Animals
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Humans
Idioma:
En
Revista:
Chembiochem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido