Importance of the Major Histocompatibility Complex (Swine Leukocyte Antigen) in Swine Health and Biomedical Research.
Annu Rev Anim Biosci
; 8: 171-198, 2020 02 15.
Article
em En
| MEDLINE
| ID: mdl-31846353
ABSTRACT
In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA) complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and class III regions mapping to 7p1.1 and the class II region mapping to 7q1.1. The swine MHC is divided by the centromere, which is unique among mammals studied to date. The SLA complexspans between 2.4 and 2.7 Mb, depending on haplotype, and encodes approximately 150 loci, with at least 120 genes predicted to be functional. Here we update the whole SLA complex based on the Sscrofa11.1 build and annotate the organization for all recognized SLA genes and their allelic sequences. We present SLA nomenclature and typing methods and discuss the expression of SLA proteins, as well as their role in antigen presentation and immune, disease, and vaccine responses. Finally, we explore the role of SLA genes in transplantation and xenotransplantation and their importance in swine biomedical models.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suínos
/
Antígenos de Histocompatibilidade Classe I
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Annu Rev Anim Biosci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Áustria