Ankylosis of hock joints in group caged male B6C3F1 mice.
Lab Anim Sci
; 38(4): 417-21, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-3184849
ABSTRACT
Enlarged hock joints were observed during 1983 in B6C3F1 mice of chronic toxicity and carcinogenicity studies sponsored by the National Toxicology Program (NTP). Subsequently, approximately 9,500 B6C3F1 mice on 32 NTP chemical toxicity and carcinogenicity studies were evaluated for this condition by clinical examination. Group caged male B6C3F1 mice had thickening and reduced mobility of the hock joints at prevalences of 1.2% up to 6 months of age; 23% at 6 to 12 months of age; and 62% at 13 to 26 months of age. Group caged female B6C3F1 mice had a prevalence of 2% or less. Histologically, affected mice had periarticular exostoses on the bones of the hock joints, with formation of bony bridges around joints and deposition of new bone in joint spaces, resulting in partial or complete ankylosis. Individually caged male and female B6C3F1 mice were not affected. The cause of the ankylosis was not determined, but its occurrence in the NTP studies has been reduced by individual caging.
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Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Abrigo para Animais
/
Articulações
/
Anquilose
/
Camundongos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Lab Anim Sci
Ano de publicação:
1988
Tipo de documento:
Article