Can the basal serum thyroglobulin level be used to predict the recombinant human TSH-stimulated thyroglobulin level in differentiated patients with thyroid cancer?
Medicine (Baltimore)
; 98(51): e18437, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31861014
ABSTRACT
This study investigated the correlation between basal thyroglobulin (Tg) and recombinant human thyroid-stimulating hormone (rhTSH)-stimulated Tg in differentiated patients with thyroid cancer, and sought to determine whether the basal Tg level predicts the rhTSH-stimulated Tg level.We retrospectively enrolled 177 patients with papillary thyroid cancer (mean age =â44 years; 50 males, 127 females) who received rhTSH before radioiodine therapy (RIT). Serum Tg levels were measured 7 days before the 1st rhTSH injection (basal Tg) and on the days of RIT (rhTSH-stimulated Tg). Patients were divided into 3 groups according to rhTSH-stimulated Tg cut-off levels of 2, 5, and 10âng/mL. The correlation between basal Tg and rhTSH-stimulated Tg levels was assessed, and whether basal Tg was useful in predicting the rhTSH-stimulated Tg level was determined.A significant positive correlation was observed between basal and rhTSH-stimulated Tg levels (|rho| =â0.48, Pâ<â.0001). The basal Tg level had significant diagnostic ability in predicting an rhTSH-stimulated Tg level of 2âng/mL or higher, and the optimal basal Tg level for this prediction was 0.3âng/mL (AUC =â0.77, Pâ<â.0001). A basal Tg level of 0.5âng/mL was optimal for predicting rhTSH-stimulated Tg levels of 5âng/mL or higher (AUC =â0.81, Pâ<â.0001), and of 10âng/mL or higher (AUC =â0.82, Pâ=â.0171).The basal Tg level was significantly correlated with the rhTSH-stimulated Tg level. If the basal Tg level is >0.3 or 0.5âng/mL, then the rhTSH-stimulated Tg level can be expected to be sufficiently high to necessitate clinical examination.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tireoglobulina
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Neoplasias da Glândula Tireoide
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Câncer Papilífero da Tireoide
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2019
Tipo de documento:
Article