Preparation, optimization, and in-vitro characterization of α-tocopherol-loaded solid lipid nanoparticles (SLNs).
Drug Dev Ind Pharm
; 46(1): 159-171, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31894713
ABSTRACT
Objective:
The main scope of present investigation was preparation and physicochemical characterization of solid lipid nanoparticles (SLNs) loaded by α-tocopherol acetate (ATA).Methods:
ATA-loaded nanoparticles were prepared by solvent injection-homogenization technique using stearic acid as the solid lipid, phosphatidylcholine as the stabilizer and finally coated by chitosan with the aim of increasing z-potential and also having a more stable nano-formulation. Then, characterization of SLNs has been conducted using dynamic light scattering (DLS), zeta potential measurement, Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).Results:
Nanoparticles with average sizes of 175 ± 15 nm and zeta potential of +35 ± 2.5 mV were obtained. An excellent drug entrapment efficiency of 90.58 ± 1.38% was obtained with a no-burst slow release up to about 10 days tested. The final plateau of release of ATA from nanoparticulate system within 216 h was 61.13 ± 0.13% which was approached in about 150 h. Physical stability studies showed that the ATA nano-formulation remained stable with slight increase in mean particle size and polydispersity index over a 3-month period in refrigerated temperature. Considering both FTIR and DSC analysis, it can be concluded that there is no new band formation between materials and ATA in our nano-formulation. Particle sizes obtained using AFM images are in a good agreement to those established from the DLS analysis.Conclusion:
These data showed a promising delivery system for vitamin E based on SLN platform.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Alfa-Tocoferol
/
Nanopartículas
/
Lipídeos
Idioma:
En
Revista:
Drug Dev Ind Pharm
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Irã