Difference in the hypoxic immunosuppressive microenvironment of patients with neurofibromatosis type 2 schwannomas and sporadic schwannomas.

Tamura, Ryota; Morimoto, Yukina; Sato, Mizuto; Kuranari, Yuki; Oishi, Yumiko; Kosugi, Kenzo; Yoshida, Kazunari; Toda, Masahiro

Tamura, Ryota; Morimoto, Yukina; Sato, Mizuto; Kuranari, Yuki; Oishi, Yumiko; Kosugi, Kenzo; Yoshida, Kazunari; Toda, Masahiro.

Afiliação

Tamura R; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Morimoto Y; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Sato M; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kuranari Y; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Oishi Y; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kosugi K; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Yoshida K; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Toda M; Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. todam@keio.jp.

J Neurooncol ; 146(2): 265-273, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31897926

Assuntos

Biomarcadores Tumorais/metabolismo; Hipóxia; Terapia de Imunossupressão; Neurilemoma/imunologia; Neurofibromatose 2/imunologia; Microambiente Tumoral/imunologia; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Antígeno B7-H1/metabolismo; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Neurilemoma/metabolismo; Neurilemoma/patologia; Neurofibromatose 2/metabolismo; Neurofibromatose 2/patologia; Prognóstico; Taxa de Sobrevida; Células Tumorais Cultivadas; Adulto Jovem

Palavras-chave

Hypoxia; NF2; PD-1; PD-L1; Schwannoma; Treg: TAM

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Terapia de Imunossupressão / Neurofibromatose 2 / Microambiente Tumoral / Hipóxia / Neurilemoma Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurooncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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