CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFß.

Chen, Ruo; Wang, Ke; Feng, Zhuan; Zhang, Ming-Yang; Wu, Jiao; Geng, Jie-Jie; Chen, Zhi-Nan

Chen, Ruo; Wang, Ke; Feng, Zhuan; Zhang, Ming-Yang; Wu, Jiao; Geng, Jie-Jie; Chen, Zhi-Nan.

Afiliação

Chen R; Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangdong, China.
Wang K; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China.
Feng Z; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China.
Zhang MY; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China.
Wu J; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China.
Geng JJ; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China.
Chen ZN; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Shaanxi, China. gengjie-jie@163.com.

Cell Mol Immunol ; 18(1): 171-181, 2021 01.

Article em En | MEDLINE | ID: mdl-31900457

Assuntos

Envelhecimento; Células Epiteliais/fisiologia; Transição Epitelial-Mesenquimal; Linfócitos T/metabolismo; Timo/fisiologia; Fator de Crescimento Transformador beta/metabolismo; Animais; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas Tirosina Fosfatases Classe 3 Semelhantes a Receptores/fisiologia; Transdução de Sinais; Linfócitos T/imunologia; Fator de Crescimento Transformador beta/genética

Palavras-chave

CD147; EMT; TGFß; thymic involution

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timo / Envelhecimento / Linfócitos T / Fator de Crescimento Transformador beta / Células Epiteliais / Transição Epitelial-Mesenquimal Limite: Animals Idioma: En Revista: Cell Mol Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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