Eculizumab for Severe Thrombotic Microangiopathy Secondary to Surgical Invasive Stress and Bleeding.
Intern Med
; 59(1): 93-99, 2020.
Article
em En
| MEDLINE
| ID: mdl-31902910
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is an extremely rare condition caused by an excessive activation of the complement pathway based on genetic or acquired dysfunctions in complement regulation, leading to thrombotic microangiopathy (TMA). A complement-amplifying condition (CAC) can trigger aHUS occurrence along with complement abnormality. We herein report a case of severe TMA after laparoscopic myomectomy in a healthy woman. This case was eventually diagnosed as complement-mediated TMA secondary to surgical invasive stress as a CAC, with no definitive diagnosis of aHUS despite a genetic test. The patient fully recovered after several eculizumab administrations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Laparoscopia
/
Hemorragia Pós-Operatória
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Microangiopatias Trombóticas
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Anticorpos Monoclonais Humanizados
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Miomectomia Uterina
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão