Cognitive and physical markers of prodromal dementia: A 12-year-long population study.
Alzheimers Dement
; 16(1): 153-161, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31914224
ABSTRACT
INTRODUCTION:
The aim is to test whether adding a simple physical test such as walking speed (WS) to the neuropsychological assessment increases the predictive ability to detect dementia.METHODS:
The 2546 dementia-free people from the SNAC-K study were grouped into four profiles (1) healthy profile; (2) isolated cognitive impairment, no dementia (CIND, scoring 1.5 standard deviation below age-specific means on ≥1 cognitive domains); (3) isolated slow WS (<0.8 m/s); (4) CIND+ slow WS. The hazard of dementia (Cox regression), the positive and negative predictive values (PPV, NPV), and the area under the curve (AUC) were estimated.RESULTS:
Participants with CIND +slow WS demonstrated the highest hazard of dementia (3.4; 95% confidence interval [CI] 2.5-4.8). The AUC increased from 0.69 for isolated CIND to 0.83 for CIND+ slow WS. Such an increase was due to the improvement of the PPV, the NPV remaining optimal.DISCUSSION:
Adding WS to the cognitive assessment dramatically increases the diagnostic accuracy of prodromal dementia.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caminhada
/
Transtornos Cognitivos
/
Demência
/
Sintomas Prodrômicos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suécia