Highly efficient base editing with expanded targeting scope using SpCas9-NG in rabbits.

Liu, Zhiquan; Shan, Huanhuan; Chen, Siyu; Chen, Mao; Song, Yuning; Lai, Liangxue; Li, Zhanjun

Liu, Zhiquan; Shan, Huanhuan; Chen, Siyu; Chen, Mao; Song, Yuning; Lai, Liangxue; Li, Zhanjun.

Afiliação

Liu Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Shan H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Chen S; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Chen M; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Song Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Lai L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
Li Z; CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

FASEB J ; 34(1): 588-596, 2020 01.

Article em En | MEDLINE | ID: mdl-31914687

Assuntos

Proteína 9 Associada à CRISPR/genética; Sistemas CRISPR-Cas; Embrião de Mamíferos/metabolismo; Edição de Genes/métodos; Mutação; Motivos de Nucleotídeos/genética; Adenina/química; Animais; Citosina/química; Embrião de Mamíferos/citologia; Fator 5 de Crescimento de Fibroblastos/genética; Proteínas de Homeodomínio/genética; Modelos Animais; Coelhos; Streptococcus pyogenes/genética

Palavras-chave

CRISPR/Cas9; NG PAMs; base editor; rabbit

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Embrião de Mamíferos / Motivos de Nucleotídeos / Sistemas CRISPR-Cas / Edição de Genes / Proteína 9 Associada à CRISPR / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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