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Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-ß.
Metelli, Alessandra; Wu, Bill X; Riesenberg, Brian; Guglietta, Silvia; Huck, John D; Mills, Catherine; Li, Anqi; Rachidi, Saleh; Krieg, Carsten; Rubinstein, Mark P; Gewirth, Daniel T; Sun, Shaoli; Lilly, Michael B; Wahlquist, Amy H; Carbone, David P; Yang, Yiping; Liu, Bei; Li, Zihai.
Afiliação
  • Metelli A; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Wu BX; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
  • Riesenberg B; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
  • Guglietta S; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Huck JD; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA.
  • Mills C; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Li A; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
  • Rachidi S; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Krieg C; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Rubinstein MP; Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Gewirth DT; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Sun S; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA.
  • Lilly MB; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Wahlquist AH; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Carbone DP; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Yang Y; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
  • Liu B; Division of Medical Oncology, The Ohio State University, Columbus, OH 43210, USA.
  • Li Z; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Sci Transl Med ; 12(525)2020 01 08.
Article em En | MEDLINE | ID: mdl-31915300
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Trombina / Proteínas de Ligação a TGF-beta Latente / Evasão da Resposta Imune / Proteólise / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Trombina / Proteínas de Ligação a TGF-beta Latente / Evasão da Resposta Imune / Proteólise / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos