Effect of tofogliflozin and pioglitazone on hepatic steatosis in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A randomized, open-label pilot study (ToPiND study).

Ozaki, Anna; Yoneda, Masato; Kessoku, Takaomi; Iwaki, Michihiro; Kobayashi, Takashi; Honda, Yasushi; Ogawa, Yuji; Imajo, Kento; Sakai, Eiji; Taguri, Masataka; Yamanaka, Takeharu; Iwasaki, Tomoyuki; Kurihashi, Takeo; Saito, Satoru; Nakajima, Atsushi

Ozaki, Anna; Yoneda, Masato; Kessoku, Takaomi; Iwaki, Michihiro; Kobayashi, Takashi; Honda, Yasushi; Ogawa, Yuji; Imajo, Kento; Sakai, Eiji; Taguri, Masataka; Yamanaka, Takeharu; Iwasaki, Tomoyuki; Kurihashi, Takeo; Saito, Satoru; Nakajima, Atsushi.

Afiliação

Ozaki A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Yoneda M; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Kessoku T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Iwaki M; Department of Palliative Care Center Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Kobayashi T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Honda Y; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Ogawa Y; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Imajo K; Department of Palliative Care Center Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Sakai E; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Taguri M; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Yamanaka T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Iwasaki T; Department of Data Science, Yokohama City University School of Data Science, 2-22 Seto, Kanazawa-ku, Yokohama, 236-0027, Japan.
Kurihashi T; Department of Biostatistics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Saito S; Iwasaki Internal Medicine Clinic, 1-1-5 Furu-ruyokohama1F, Kamihoshikawa, Hodogaya-ku, Yokohama, Kanagawa, 240-0042, Japan.
Nakajima A; Department of Internal Medicine, Yokohama Clinic, Kanagawa Dental University, 3-31-6 Tsuruya-cho, Kanagawa, Yokohama, Kanagawa, 221-0835, Japan.

Contemp Clin Trials Commun ; 17: 100516, 2020 Mar.

Article em En | MEDLINE | ID: mdl-31956725

Palavras-chave

AE, adverse event; ALT, alanine aminotransferase; CRF, case report form; DM, diabetes mellitus; Diabetes mellitus; FAS, full analysis set; HbA1c, glycated hemoglobin; Hepatic steatosis; MRI-Based proton density fat fraction; MRI-PDFF, magnetic resonance imaging-based proton density fat fraction; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; Non-alcoholic fatty liver disease; PPS, per protocol set; Pioglitazone; SPIRIT, the Standard Protocol Items: Recommendations for Interventional Trials; Tofogliflozin; jRCTs, the Japan Registry of Clinical Trials

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Idioma: En Revista: Contemp Clin Trials Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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