Your browser doesn't support javascript.
loading
Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.
Kahremany, Shirin; Babaev, Ilana; Hasin, Pinhas; Tamir, Tigist Y; Ben-Zur, Tali; Cohen, Guy; Jiang, Zhengyu; Weintraub, Sagiv; Offen, Daniel; Rahimipour, Shai; Major, M Ben; Senderowitz, Hanoch; Gruzman, Arie.
Afiliação
  • Kahremany S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Babaev I; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Hasin P; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Tamir TY; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Ben-Zur T; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
  • Cohen G; The Skin Research Institute, The Dead Sea & Arava Science Center, Tamar Regional Council, Dead Sea Mobile Post, 86910, Israel.
  • Jiang Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University Nanjing, Jiangsu, 210008, P. R. China.
  • Weintraub S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Offen D; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
  • Rahimipour S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Major MB; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Senderowitz H; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Gruzman A; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
Chempluschem ; 83(5): 318, 2018 May.
Article em En | MEDLINE | ID: mdl-31957368
ABSTRACT
Invited for this month's cover is Prof. Arie Gruzman (Bar-Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose- and time-dependent manner and protected PC-12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative-stress-related diseases. Read the full text of the article at 10.1002/cplu.201700539.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Chempluschem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Chempluschem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel