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A framework for advancing our understanding of cancer-associated fibroblasts.
Sahai, Erik; Astsaturov, Igor; Cukierman, Edna; DeNardo, David G; Egeblad, Mikala; Evans, Ronald M; Fearon, Douglas; Greten, Florian R; Hingorani, Sunil R; Hunter, Tony; Hynes, Richard O; Jain, Rakesh K; Janowitz, Tobias; Jorgensen, Claus; Kimmelman, Alec C; Kolonin, Mikhail G; Maki, Robert G; Powers, R Scott; Puré, Ellen; Ramirez, Daniel C; Scherz-Shouval, Ruth; Sherman, Mara H; Stewart, Sheila; Tlsty, Thea D; Tuveson, David A; Watt, Fiona M; Weaver, Valerie; Weeraratna, Ashani T; Werb, Zena.
Afiliação
  • Sahai E; The Francis Crick Institute, London, UK. erik.sahai@crick.ac.uk.
  • Astsaturov I; Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Cukierman E; Cancer Biology Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • DeNardo DG; Division of Oncology, Washington University Medical School, St Louis, MO, USA.
  • Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Fearon D; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Greten FR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Hingorani SR; Weill Cornell Medicine, New York, NY, USA.
  • Hunter T; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Hynes RO; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany.
  • Jain RK; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Janowitz T; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Jorgensen C; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kimmelman AC; Edwin L Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Kolonin MG; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Maki RG; Northwell Health Cancer Institute, New Hyde Park, NY, USA.
  • Powers RS; Cancer Research UK Manchester Institute, University of Manchester, Nether Alderley, UK.
  • Puré E; Department of Radiation Oncology, Perlmutter Cancer Center, New York University Medical Center, New York, NY, USA.
  • Ramirez DC; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA.
  • Scherz-Shouval R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Sherman MH; Northwell Health Cancer Institute, New York, NY, USA.
  • Stewart S; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Tlsty TD; Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
  • Tuveson DA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Watt FM; Zucker School of Medicine at Hofstra/Northwell Health System, New York, NY, USA.
  • Weaver V; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
  • Weeraratna AT; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
  • Werb Z; Department of Cell Biology and Physiology, Department of Medicine, ICCE Institute, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Nat Rev Cancer ; 20(3): 174-186, 2020 03.
Article em En | MEDLINE | ID: mdl-31980749
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microambiente Tumoral / Fibroblastos Associados a Câncer / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Rev Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microambiente Tumoral / Fibroblastos Associados a Câncer / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Rev Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article