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Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, Pilar; Muñoz-Fuentes, Violeta; Murray, Stephen A; Dickinson, Mary E; Bucan, Maja; Nutter, Lauryl M J; Peterson, Kevin A; Haselimashhadi, Hamed; Flenniken, Ann M; Morgan, Hugh; Westerberg, Henrik; Konopka, Tomasz; Hsu, Chih-Wei; Christiansen, Audrey; Lanza, Denise G; Beaudet, Arthur L; Heaney, Jason D; Fuchs, Helmut; Gailus-Durner, Valerie; Sorg, Tania; Prochazka, Jan; Novosadova, Vendula; Lelliott, Christopher J; Wardle-Jones, Hannah; Wells, Sara; Teboul, Lydia; Cater, Heather; Stewart, Michelle; Hough, Tertius; Wurst, Wolfgang; Sedlacek, Radislav; Adams, David J; Seavitt, John R; Tocchini-Valentini, Glauco; Mammano, Fabio; Braun, Robert E; McKerlie, Colin; Herault, Yann; de Angelis, Martin Hrabe; Mallon, Ann-Marie; Lloyd, K C Kent; Brown, Steve D M; Parkinson, Helen; Meehan, Terrence F; Smedley, Damian.
Afiliação
  • Cacheiro P; Clinical Pharmacology, William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Muñoz-Fuentes V; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Murray SA; The Jackson Laboratory, Bar Harbor, ME, 4609, USA.
  • Dickinson ME; Departments of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Bucan M; Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Nutter LMJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Peterson KA; The Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, M5T 3H7, Canada.
  • Haselimashhadi H; The Jackson Laboratory, Bar Harbor, ME, 4609, USA.
  • Flenniken AM; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Morgan H; The Centre for Phenogenomics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5T 3H7, Canada.
  • Westerberg H; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Konopka T; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Hsu CW; Clinical Pharmacology, William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Christiansen A; Departments of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Lanza DG; Departments of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Beaudet AL; Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Heaney JD; Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Fuchs H; Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Sorg T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Prochazka J; Université de Strasbourg, CNRS, INSERM, Institut Clinique de la Souris, PHENOMIN-ICS, 67404, Illkirch, France.
  • Novosadova V; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, 252 50, Prague, Czech Republic.
  • Lelliott CJ; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, 252 50, Prague, Czech Republic.
  • Wardle-Jones H; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Wells S; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Teboul L; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Cater H; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Stewart M; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Hough T; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Wurst W; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Sedlacek R; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany.
  • Adams DJ; Department of Developmental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, 85764, Neuherberg, Germany.
  • Seavitt JR; Deutsches Institut für Neurodegenerative Erkrankungen (DZNE) Site Munich, Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität München, 80336, Munich, Germany.
  • Tocchini-Valentini G; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, 252 50, Prague, Czech Republic.
  • Mammano F; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Braun RE; Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • McKerlie C; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, 00015, Monterotondo Scalo, Italy.
  • Herault Y; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, 00015, Monterotondo Scalo, Italy.
  • de Angelis MH; The Jackson Laboratory, Bar Harbor, ME, 4609, USA.
  • Mallon AM; The Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, M5T 3H7, Canada.
  • Lloyd KCK; Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5T 3H7, Canada.
  • Brown SDM; Université de Strasbourg, CNRS, INSERM, Institut de Génétique, Biologie Moléculaire et Cellulaire, Institut Clinique de la Souris, IGBMC, PHENOMIN-ICS, 67404, Illkirch, France.
  • Parkinson H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Meehan TF; Department of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, 85354, Freising-Weihenstephan, Germany.
  • Smedley D; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
Nat Commun ; 11(1): 655, 2020 01 31.
Article em En | MEDLINE | ID: mdl-32005800
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença / Estudos de Associação Genética Tipo de estudo: Evaluation_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença / Estudos de Associação Genética Tipo de estudo: Evaluation_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido