Methylmercury and long chain polyunsaturated fatty acids are associated with immune dysregulation in young adults from the Seychelles child development study.
Environ Res
; 183: 109072, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32007747
ABSTRACT
BACKGROUND:
Exposure to the environmental toxicant mercury (Hg) has been associated with immune dysregulation, including autoimmune disease, but few human studies have examined methylmercury (MeHg) exposure from fish consumption.OBJECTIVES:
We examined associations between MeHg exposure and biological markers of autoimmunity and inflammation while adjusting for long chain polyunsaturated fatty acids (LCPUFA).METHOD:
At age 19 years, hair total Hg (Y19Hg), LCPUFA status, a panel of 13 antinuclear antibodies (ANA), total serum immunoglobulins (Ig) IgG, IgA, and IgM and serum markers of inflammation (IL-1, IL-2, IL-6, IL-10, C-reactive protein (CRP), IFN-γ, TNF-α) were measured in the Seychelles Child Development Study (SCDS) Main Cohort (n = 497). Multivariable regression models investigated the association between Y19Hg and biomarkers, adjusting for prenatal total hair Hg (MatHg) and other relevant covariates, and with and without adjustment for LCPUFA.RESULTS:
With each 1 ppm increase in Y19Hg (mean 10.23 (SD 6.02) ppm) we observed a 4% increased odds in a positive Combined ANA following adjustment for the n6n3 LCPUFA ratio (ß = 0.036, 95%; CI 0.001, 0.073). IgM was negatively associated with Y19Hg (ß = -0.016, 95%CI 0.016, -0.002) in models adjusted for n-3, n-6 LCPUFA and when separately adjusted for the n-6n-3 LCPUFA ratio. No associations were observed with MatHg. Total n-3 LCPUFA status was associated with reduced odds of a positive anti-ribonuclear protein (RNP) A. The n-3 LCPUFA were negatively associated with IL-6, IL-10, CRP, IFN-γ, TNF-α and positively with TNF-αIL-10. There were positive associations between the n-6n-3 ratio and IL-6, IL-10, CRP, IFN-γ, TNF-α and a negative association with TNF-αIL-10.DISCUSSION:
The Y19Hg exposure was associated with higher ANA and lower IgM albeit only following adjustment for the n-3 LCPUFA or the n-6n-3 LCPUFA ratio. The clinical significance of these findings is unclear, but warrant follow up at an older age to determine any relationship to the onset of autoimmune disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Ácidos Graxos Ômega-3
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Compostos de Metilmercúrio
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Animals
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Child
/
Female
/
Humans
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Male
/
Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2020
Tipo de documento:
Article