The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer.

Gong, Xiaofeng; Du, Danyu; Deng, Yanran; Zhou, Yuqi; Sun, Li; Yuan, Shengtao

Gong, Xiaofeng; Du, Danyu; Deng, Yanran; Zhou, Yuqi; Sun, Li; Yuan, Shengtao.

Afiliação

Gong X; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Du D; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Deng Y; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Zhou Y; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Sun L; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Yuan S; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, No. 24, Tongjiaxiang, Nanjing, China. cpuyuanst@163.com.

Invest New Drugs ; 38(2): 515-524, 2020 04.

Article em En | MEDLINE | ID: mdl-32008177

Assuntos

Neoplasias/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Animais; Humanos; Neoplasias/tratamento farmacológico; Prognóstico; Conformação Proteica; Proteínas Supressoras de Tumor/química; Ubiquitina-Proteína Ligases/química; Ubiquitinação

Palavras-chave

Cancer therapeutics; Drug discovery; HUWE1; Ubiquitination

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Supressoras de Tumor / Ubiquitina-Proteína Ligases / Neoplasias Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Invest New Drugs Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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