Learning of Signaling Networks: Molecular Mechanisms.
Trends Biochem Sci
; 45(4): 284-294, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32008897
ABSTRACT
Molecular processes of neuronal learning have been well described. However, learning mechanisms of non-neuronal cells are not yet fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins (IDPs) and prions, signaling cascades, protein translocation, RNAs [miRNA and long noncoding RNA (lncRNA)], and chromatin memory. We hypothesize that these processes constitute the learning of signaling networks and correspond to a generalized Hebbian learning process of single, non-neuronal cells, and we discuss how cellular learning may open novel directions in drug design and inspire new artificial intelligence methods.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Cromatina
/
Transdução de Sinais
/
Proteínas Intrinsicamente Desordenadas
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2020
Tipo de documento:
Article