Bioluminescence imaging of exogenous & endogenous cysteine in vivo with a highly selective probe.
Bioorg Med Chem Lett
; 30(6): 126968, 2020 03 15.
Article
em En
| MEDLINE
| ID: mdl-32008907
ABSTRACT
Cysteine (Cys) is a semi-essential amino acid that exerts a vital role in numerous biological functions. A noninvasive method for in vivo imaging of cysteine could represent a valuable tool for research cysteine and its complex contributions in living organisms. Thus, we developed a turn-on bioluminescence probe (CBP) not only for detecting exogenous and endogenous cysteine in vitro and in vivo, but also for visualizing these cysteines in whole animal. The current applications may help shed light on the complex mechanisms of cysteine in miscellaneous physiological and pathological processes.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cisteína
/
Corantes Fluorescentes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article