Lost in Translation: Cul3-Dependent Pathological Mechanisms in Psychiatric Disorders.
Neuron
; 105(3): 398-399, 2020 02 05.
Article
em En
| MEDLINE
| ID: mdl-32027827
In this issue of Neuron, Dong et al. (2020) finds that deficiency of the psychiatric risk gene Cul3, which encodes an E3 ubiquitin ligase, leads to an upregulation of Cap-dependent protein translation. The resulting imbalance in protein synthesis and degradation is found to disrupt glutamatergic transmission and excitability in networks that underlie sociability and anxiety.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Culina
/
Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos