Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1&#945; Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.

Tang, Yan-Long; Zhang, Cheng-Gui; Liu, Heng; Zhou, Yue; Wang, Ya-Ping; Li, Yuan; Han, Yan-Jun; Wang, Cui-Li

Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.

Tang, Yan-Long; Zhang, Cheng-Gui; Liu, Heng; Zhou, Yue; Wang, Ya-Ping; Li, Yuan; Han, Yan-Jun; Wang, Cui-Li.

Afiliação

Tang YL; Department of Radiology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China (mainland).
Zhang CG; Key Laboratory of Insect Biomedicine Research and Development in Yunnan Province, Dali University, Dali, Yunnan, China (mainland).
Liu H; Key Laboratory of Insect Biomedicine Research and Development in Yunnan Province, Dali University, Dali, Yunnan, China (mainland).
Zhou Y; Department of Histology and Embryology, Key Laboratory of Cell Biology, Dali University, Dali, Yunnan, China (mainland).
Wang YP; Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China (mainland).
Li Y; Department of Histology and Embryology, Key Laboratory of Cell Biology, Dali University, Dali, Yunnan, China (mainland).
Han YJ; Department of Histology and Embryology, Key Laboratory of Cell Biology, Dali University, Dali, Yunnan, China (mainland).
Wang CL; Department of Histology and Embryology, Key Laboratory of Cell Biology, Dali University, Dali, Yunnan, China (mainland).

Med Sci Monit ; 26: e918207, 2020 Feb 10.

Article em En | MEDLINE | ID: mdl-32037392

Assuntos

Biomarcadores Tumorais/metabolismo; Senescência Celular/efeitos dos fármacos; Ginsenosídeos/farmacologia; Leucemia Mieloide Aguda/patologia; Células-Tronco Neoplásicas/metabolismo; Transdução de Sinais; Sirtuína 1/metabolismo; Esclerose Tuberosa/metabolismo; ADP-Ribosil Ciclase 1/metabolismo; Antígenos CD34/metabolismo; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Regulação para Baixo/efeitos dos fármacos; Humanos; Leucemia Mieloide Aguda/metabolismo; Células-Tronco Neoplásicas/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; beta-Glucosidase/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa / Células-Tronco Neoplásicas / Leucemia Mieloide Aguda / Transdução de Sinais / Biomarcadores Tumorais / Senescência Celular / Ginsenosídeos / Sirtuína 1 Limite: Humans Idioma: En Revista: Med Sci Monit Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article

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