Association between reduced serum BDNF levels and insomnia with short sleep duration among female hospital nurses.
Sleep Med
; 68: 167-172, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32044553
ABSTRACT
OBJECTIVE:
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) is associated with sleep regulation in humans. However, its relationship with self-reported sleep problems has not been clarified. The aim of the present study was to examine the association between serum BDNF levels and sleep problems among hospital nurses.METHODS:
Participants were enrolled from among nurses working at a general hospital in Tokyo, Japan. Data from 577 women (age 35.45 ± 10.90 years) were analyzed. This cross-sectional survey was conducted from November to December 2015. Serum BDNF concentrations were evaluated. Participants completed a self-reported questionnaire on sleep including the presence or absence of insomnia symptoms (ie, difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and early morning awakening [EMA]), and sleep duration. Insomnia with short sleep duration (ISS) was defined as DIS, or DMS, or EMA; and <6 h sleep duration.RESULTS:
Among 577 participants, 21.3% reported insomnia, 41.4% slept less than 6 h, and finally 12.5% suffered from ISS. Serum BDNF levels were significantly lower in subjects with ISS than in those without ISS. The serum BDNF levels in insomniacs were significantly lower than in non-insomniacs for short sleep duration (<6 h), while serum BDNF levels did not differ between insomniacs and non-insomniacs for normal sleep duration (≥6 h).CONCLUSION:
This is the first documented study to indicate that ISS is associated with reduced serum BDNF levels. These results may lead to clarification of the underlying pathophysiological relationship between BDNF and poor sleep.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Distúrbios do Início e da Manutenção do Sono
/
Enfermeiras e Enfermeiros
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Sleep Med
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão