&#945;-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.

Zhang, Linlin; Lin, Daizong; Kusov, Yuri; Nian, Yong; Ma, Qingjun; Wang, Jiang; von Brunn, Albrecht; Leyssen, Pieter; Lanko, Kristina; Neyts, Johan; de Wilde, Adriaan; Snijder, Eric J; Liu, Hong; Hilgenfeld, Rolf

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.

Zhang, Linlin; Lin, Daizong; Kusov, Yuri; Nian, Yong; Ma, Qingjun; Wang, Jiang; von Brunn, Albrecht; Leyssen, Pieter; Lanko, Kristina; Neyts, Johan; de Wilde, Adriaan; Snijder, Eric J; Liu, Hong; Hilgenfeld, Rolf.

Afiliação

Zhang L; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany.
Lin D; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany.
Kusov Y; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany.
Nian Y; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany.
Ma Q; Shanghai Institute of Materia Medica, 201203 Shanghai, China.
Wang J; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany.
von Brunn A; Shanghai Institute of Materia Medica, 201203 Shanghai, China.
Leyssen P; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany.
Lanko K; Shanghai Institute of Materia Medica, 201203 Shanghai, China.
Neyts J; Max von Pettenkofer Institute, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
de Wilde A; Rega Institute for Medical Research, University of Leuven, 3000 Leuven, Belgium.
Snijder EJ; Rega Institute for Medical Research, University of Leuven, 3000 Leuven, Belgium.
Liu H; Rega Institute for Medical Research, University of Leuven, 3000 Leuven, Belgium.
Hilgenfeld R; Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

J Med Chem ; 63(9): 4562-4578, 2020 05 14.

Article em En | MEDLINE | ID: mdl-32045235

Assuntos

Antivirais/farmacologia; Coronavirus/efeitos dos fármacos; Enterovirus/efeitos dos fármacos; Lactamas/farmacologia; Peptidomiméticos/farmacologia; Replicação Viral/efeitos dos fármacos; Proteases Virais 3C; Animais; Antivirais/síntese química; Antivirais/metabolismo; Sítios de Ligação; Linhagem Celular Tumoral; Chlorocebus aethiops; Coronavirus/enzimologia; Proteases 3C de Coronavírus; Cristalografia por Raios X; Cisteína Endopeptidases/química; Cisteína Endopeptidases/metabolismo; Desenho de Fármacos; Enterovirus/enzimologia; Humanos; Lactamas/síntese química; Lactamas/metabolismo; Peptidomiméticos/síntese química; Peptidomiméticos/metabolismo; Inibidores de Proteases/síntese química; Inibidores de Proteases/metabolismo; Inibidores de Proteases/farmacologia; Ligação Proteica; Células Vero; Proteínas não Estruturais Virais/antagonistas & inibidores; Proteínas não Estruturais Virais/química; Proteínas não Estruturais Virais/metabolismo; Proteínas Virais/antagonistas & inibidores; Proteínas Virais/química; Proteínas Virais/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Replicação Viral / Coronavirus / Enterovirus / Peptidomiméticos / Lactamas Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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