Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking.
J Neurosci Res
; 98(6): 1046-1069, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32056298
ABSTRACT
The striatal dopamine system has long been studied in the context of reward learning, motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive behavioral states, as well as diseases like addiction, it is essential to understand the full complexity of dopamine neurons and the striatal systems they target. A growing number of studies are uncovering details of the heterogeneity in dopamine neuron subpopulations. Here, we review that work to synthesize current understanding of dopamine system heterogeneity across three levels, anatomical organization, functions in behavior, and modes of action, wherein we focus on signaling profiles and local mechanisms for modulation of dopamine release. Together, these studies reveal new and emerging dimensions of the striatal dopamine system, informing its contribution to dynamic motivational and decision-making processes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recompensa
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Área Tegmentar Ventral
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Corpo Estriado
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Neurônios Dopaminérgicos
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Núcleo Accumbens
Limite:
Animals
Idioma:
En
Revista:
J Neurosci Res
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos