Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity.

Zurlinden, Todd J; Saili, Katerine S; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S; Houck, Keith A; Hunter, E Sidney; Baker, Nancy C; Palmer, Jessica A; Thomas, Russell S; Knudsen, Thomas B

Zurlinden, Todd J; Saili, Katerine S; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S; Houck, Keith A; Hunter, E Sidney; Baker, Nancy C; Palmer, Jessica A; Thomas, Russell S; Knudsen, Thomas B.

Afiliação

Zurlinden TJ; National Center for Computational Toxicology (NCCT).
Saili KS; National Center for Computational Toxicology (NCCT).
Rush N; National Center for Computational Toxicology (NCCT).
Kothiya P; National Center for Computational Toxicology (NCCT).
Judson RS; National Center for Computational Toxicology (NCCT).
Houck KA; National Center for Computational Toxicology (NCCT).
Hunter ES; National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), U.S. Environmental Protection Agency (USEPA), Research Triangle Park, North Carolina.
Baker NC; Leidos, Research Triangle Park, North Carolina.
Palmer JA; Stemina Biomarker Discovery, Inc, Madison, Wisconsin.
Thomas RS; National Center for Computational Toxicology (NCCT).
Knudsen TB; National Center for Computational Toxicology (NCCT).

Toxicol Sci ; 174(2): 189-209, 2020 04 01.

Article em En | MEDLINE | ID: mdl-32073639

Assuntos

Alternativas aos Testes com Animais; Células-Tronco Pluripotentes/efeitos dos fármacos; Testes de Toxicidade; Animais; Bioensaio; Biomarcadores/metabolismo; Linhagem Celular; Bases de Dados Factuais; Relação Dose-Resposta a Droga; Ensaios de Triagem em Larga Escala; Humanos; Células-Tronco Pluripotentes/metabolismo; Células-Tronco Pluripotentes/patologia; Medição de Risco

Palavras-chave

developmental toxicity; embryonic stem cells; predictive toxicology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Células-Tronco Pluripotentes / Alternativas aos Testes com Animais Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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