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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Bradley, Sophie J; Molloy, Colin; Valuskova, Paulina; Dwomoh, Louis; Scarpa, Miriam; Rossi, Mario; Finlayson, Lisa; Svensson, Kjell A; Chernet, Eyassu; Barth, Vanessa N; Gherbi, Karolina; Sykes, David A; Wilson, Caroline A; Mistry, Rajendra; Sexton, Patrick M; Christopoulos, Arthur; Mogg, Adrian J; Rosethorne, Elizabeth M; Sakata, Shuzo; John Challiss, R A; Broad, Lisa M; Tobin, Andrew B.
Afiliação
  • Bradley SJ; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. sophie.bradley@glasgow.ac.uk.
  • Molloy C; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Valuskova P; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Dwomoh L; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Scarpa M; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Rossi M; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Finlayson L; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Svensson KA; Eli Lilly & Co, Neuroscience Discovery, Lilly Corporate Center, Indianapolis, IN, USA.
  • Chernet E; Eli Lilly & Co, Neuroscience Discovery, Lilly Corporate Center, Indianapolis, IN, USA.
  • Barth VN; Eli Lilly & Co, Neuroscience Discovery, Lilly Corporate Center, Indianapolis, IN, USA.
  • Gherbi K; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
  • Sykes DA; Excellerate Bioscience Ltd, BioCity, Nottingham, UK.
  • Wilson CA; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
  • Mistry R; Centre of Membrane and Protein and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
  • Sexton PM; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
  • Christopoulos A; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, UK.
  • Mogg AJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
  • Rosethorne EM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
  • Sakata S; Eli Lilly & Co, Neuroscience Discovery, Lilly Corporate Center, Indianapolis, IN, USA.
  • John Challiss RA; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
  • Broad LM; Centre of Membrane and Protein and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
  • Tobin AB; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Nat Chem Biol ; 16(3): 240-249, 2020 03.
Article em En | MEDLINE | ID: mdl-32080630
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Muscarínico M1 Limite: Animals Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Muscarínico M1 Limite: Animals Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido