Ac2O, acetic anhydride; AcOH, acetic acid; AcONa, sodium acetate; BF3·Et2O, boron trifluoride diethyl etherate; Cancer multidrug resistance; DCE, dichloroethane; DCM, dichloromethane; DMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; DOX, doxorubicin; Et3N, triethylamine; Flutax-2, a fluorescent taxol derivative; MDR, multidrug resistance; Mechanism; NIS, N-iodosuccinimide; NOB, nobiletin; Nobiletin; P-gp inhibition; P-gp, P-glycoprotein; PI, propidium iodide; PTX, paclitaxel; QND, quinidine; Reversal agents; Rho123, rhodamine 123; SRB, sulforhodamine B; Solubility; TCA, trichloroacetic acid; THF, tetrahydrofuran; TLC, thin-layer chromatography; Total synthesis; Ver, verapamil; t-BuOK, potassium tert-butylate