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Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats.
Mahgoub, Shahenda; Sallam, Anas O; Sarhan, Hazem K A; Ammar, Amal A A; Soror, Sameh H.
Afiliação
  • Mahgoub S; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo, 11795, Egypt. Electronic address: shahenda.mahgoub@pharm.helwan.edu.eg.
  • Sallam AO; Medical Department, Nuclear Material Authority, Cairo, Egypt. Electronic address: Anas.sallam11@gmail.com.
  • Sarhan HKA; Medical and Radiation Research Department, Research Sector, Nuclear Material Authority, Cairo, Egypt. Electronic address: Hazem_Kamel1980@yahoo.com.
  • Ammar AAA; Medical and Radiation Research Department, Research Sector, Nuclear Material Authority, Cairo, Egypt. Electronic address: amalammar2016@gmail.com.
  • Soror SH; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo, 11795, Egypt. Electronic address: sameh_soror@pharm.helwan.edu.eg.
Regul Toxicol Pharmacol ; 113: 104622, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32087353
The benchmark of this study is to evaluate the radio protective efficiency of diosmin, a natural citrus flavone of hesperidin derivative on radiation-induced damage in wistar albino rats. Rats orally administered two diosmin doses (100 and 200 mg/kg body wt.) for a month (every other day) prior to exposure to high gamma radiation single dose (8Gy) or cumulative dose (10Gy). To evaluate the radio protective efficiency of diosmin various biochemical estimations, histopathological alterations as well as comet assay and caspase-3 activity for assessment of apoptosis were performed. Results indicated that radiation-induced decline in the levels of antioxidant parameters (SOD and GSH), increased lipid peroxidation, DNA damage and apoptosis were improved by pre-administration of diosmin. Diosmin dose (200 mg/kg body wt.) restored the antioxidant status to near normal and reduced lipid peroxidation, DNA and tissue damage. These results were confirmed by histopathological examinations, which showed that pre-administration of diosmin protected the liver and kidney of albino rats against gamma-irradiation induced damage. Hence, it has been illustrated that diosmin might be an effective radio protector against radiation-induced damage in rats. Moreover, diosmin alone pretreated group did not show any biochemical alterations or DNA damage indicating the protective nature of the drug.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Substâncias Protetoras / Diosmina / Raios gama Limite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Substâncias Protetoras / Diosmina / Raios gama Limite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2020 Tipo de documento: Article