Leptin promotes the fat preference associated with low-temperature acclimation in mice.
Biosci Biotechnol Biochem
; 84(6): 1250-1258, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32093588
ABSTRACT
Although fluctuations in energy metabolism are known to influence intake as well as nutrient selection, there are no definitive reports on how food preferences change with changes in habitat temperature. We investigated the effects of habitat temperature on appetite and food preference and elucidated the underlying mechanism by conducting a feeding experiment and a leptin administration test on mice reared at low temperatures. Our results showed that the increased food intake and HFD preference observed in the 10°C group were induced by decrease in plasma leptin concentration. Then, a leptin administration experiment was conducted to clarify the relationship between leptin and food preference with low-temperature acclimation. The control group reared in 10°C significantly preferred the HFD, but the leptin-administered group did not. These results show that the peripheral system appetite-regulating hormone leptin not only acts to suppress appetite but also might inhibit preference for lipids in low-temperature acclimation.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressores do Apetite
/
Temperatura Baixa
/
Leptina
/
Ingestão de Alimentos
/
Dieta Hiperlipídica
/
Preferências Alimentares
/
Aclimatação
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão