Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.

Zhong, Wenying; Tang, Xinwen; Liu, Yang; Zhou, Chunyu; Liu, Pan; Li, Enhui; Zhong, Peilin; Lv, Haoxue; Zou, Qiang; Wang, Maolin

Zhong, Wenying; Tang, Xinwen; Liu, Yang; Zhou, Chunyu; Liu, Pan; Li, Enhui; Zhong, Peilin; Lv, Haoxue; Zou, Qiang; Wang, Maolin.

Afiliação

Zhong W; Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.
Tang X; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Liu Y; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Zhou C; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Liu P; College of Biological Science and Technology, Chengdu Medical College, Chengdu 610500, China.
Li E; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Zhong P; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Lv H; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Zou Q; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Wang M; Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.

Molecules ; 25(4)2020 Feb 21.

Article em En | MEDLINE | ID: mdl-32098126

Assuntos

Benzoxazóis/farmacologia; Linfoma/tratamento farmacológico; Proteínas Quinases S6 Ribossômicas 70-kDa/genética; Serina-Treonina Quinases TOR/genética; Animais; Antineoplásicos Fitogênicos/farmacologia; Apoptose/efeitos dos fármacos; Autofagia/efeitos dos fármacos; Benzoxazóis/química; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Leucócitos Mononucleares; Linfoma/genética; Linfoma/patologia; Camundongos; Células RAW 264.7; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

B-cell Burkitt's lymphoma; B-cell acute lymphoblastic leukemia; K313; apoptosis; autophagy blockage; cell cycle arrest; mitochondrial pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoxazóis / Proteínas Quinases S6 Ribossômicas 70-kDa / Serina-Treonina Quinases TOR / Linfoma Limite: Animals / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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